Studies of Nucleosides and Nucleotides. XXXIX. Synthesis of 8-Substituted Purine Nucleotides by the Direct Replacement Reactions

Enzymatic synthesis of purine nucleotides.

The demonstration of a pathway of pyrimidine nucleotide synthesis in which PRPP’ is a key intermediate (1, 2) prompted a study to determine whether the same type of reaction mechanism might apply to the synthesis of purine nucleotides. In a preliminary note the condensation of adenine with PRPP to yield A5P was reported (3). Subsequent work has established the existence of enzymes in yeast whic...

Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents.

A series of 2'-substituted cyclobutyl nucleoside analogs were efficiently prepared by constructing the core cyclobutyl ring using different [2+2] cycloaddition approaches. The triphosphate derivative of a cyclobutyl nucleoside was also synthesized and evaluated against wild-type and mutant HIV reverse transcriptases (RT). Whereas the nucleoside analogs were inactive against HIV-1 in culture, th...

Nucleosides, Nucleotides and Nucleic Acids

To cite this article: Krzysztof Komodziński, Zofia Gdaniec & Bohdan Skalski (2015) Photochemical Behavior of 2-Azidopurine Tri-O-Acetylribonucleoside in Aqueous Solution: Unprecedented Transformation into 1-(5′-O-Acetyl-β-D-Ribofuranosyl)-5-[(2-Oxo-1,3,5Oxadiazocan-4-Ylidene)Amino]-1H-Imidazole-4-Carbaldehyde, Nucleosides, Nucleotides and Nucleic Acids, 34:4, 235-245, DOI: 10.1080/15257770.2014...

The Chemistry of Nucleosides and Nucleotides

It seems amazing that a research worker as prolific as Dr. Michelson should have been able to find time to write this excellent volume with its more than two thousand references. It is admirable that a publisher should be able to print a book in 1963 in which so many late 1962 references are included. The degree of completeness with which the organic and physical chemistry of nucleosides, nucle...

Nucleosides, Nucleotides and Nucleic Acids